Production of proteins in glutamine-free cell culture media

US12351641B2 · 07/08/2025

FIG. 1 · Sheet 1

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The present invention relates generally to glutamine-free cell culture media supplemented with arginine. The invention further concerns the production of recombinant proteins, such as therapeutic IgG antibodies, in a Chinese hamster ovary (CHO) host cell in a production phase culture medium that …

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Abstract The present invention relates generally to glutamine-free cell culture media supplemented with arginine. The invention further concerns the production of recombinant proteins, such as therapeutic IgG antibodies, in a Chinese hamster ovary (CHO) host cell in a production phase culture medium that is essentially free of glutamine and comprises arginine in arginine.

Official name

Production of proteins in glutamine-free cell culture media

Publication number

US12351641B2

Inventor / creator

Martin Gawlitzek

Assignee / owner

Genentech, Inc.

Filing

11/08/2024

Publication

07/08/2025

Expiry

11/08/2044

Status

ACTIVE

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