Synthesis of key intermediate of KRAS G12C inhibitor compound

US12391691B2 · 08/19/2025

FIG. 1 · Sheet 1

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The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structureuseful for the synthesis of compounds that target KRAS G12C mutations, such as

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Abstract The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structureuseful for the synthesis of compounds that target KRAS G12C mutations, such as

Official name

Synthesis of key intermediate of KRAS G12C inhibitor compound

Publication number

US12391691B2

Inventor / creator

Andrew Thomas PARSONS

Assignee / owner

Amgen Inc.

Filing

12/19/2024

Publication

08/19/2025

Expiry

12/19/2044

Status

ACTIVE

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